Related Experiment Videos
[Gingival hyperplasia induced by cyclosporin A]
V Cervelli1, F Guidiceandrea, G M Pigliucci
1Clinica Chirurgica, IIa Università di Roma Tor Vergata.
Rivista Europea Per Le Scienze Mediche E Farmacologiche = European Review for Medical and Pharmacological Sciences = Revue Europeenne Pour Les Sciences Medicales Et Pharmacologiques
|July 1, 1992
Summary
Cyclosporine-A, an immunosuppressant, can cause gingival hyperplasia in kidney transplant patients. This study reviews the condition and presents findings from 10 such cases.
Area of Science:
- Immunology
- Pharmacology
- Oral Medicine
Context:
- Cyclosporine-A (Cy-A) is a vital immunosuppressant in organ transplantation.
- Gingival hyperplasia is a known side effect of certain medications, including Cy-A.
- Kidney transplantation patients on Cy-A therapy are susceptible to this adverse effect.
Purpose:
- To review the latest pathogenetic hypotheses of drug-induced gingival hyperplasia.
- To present clinical experience with 10 cases of gingival hyperplasia in kidney transplant recipients treated with Cy-A.
- To correlate Cy-A treatment with the occurrence of gingival hyperplasia.
Summary:
- Cyclosporine-A selectively inhibits T cell function, impacting transplantation success.
- Gingival hyperplasia is an adverse drug reaction observed in some patients undergoing Cy-A therapy.
- The study details 10 cases of kidney transplant patients experiencing gingival hyperplasia while on Cy-A.
Impact:
- Highlights a significant oral side effect of Cyclosporine-A in transplant patients.
- Contributes to understanding the pathogenesis of drug-induced gingival overgrowth.
- Informs clinical management strategies for immunosuppressed patients experiencing gingival hyperplasia.