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Histologic study of chronic active hepatitis C; comparison with chronic active hepatitis B
1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
The Korean Journal of Internal Medicine
|July 1, 1992
Summary
Histologic findings in chronic active hepatitis C (CAH-C) were compared to chronic active hepatitis B (CAH-B). Follicular portal inflammation and sinusoidal lymphocytic reactions are key indicators for CAH-C.
Area of Science:
- Hepatology
- Virology
- Pathology
Background:
- Histologic findings for chronic active hepatitis C (CAH-C) are not well-defined.
- Distinguishing CAH-C from chronic active hepatitis B (CAH-B) histologically is important for patient management.
Purpose of the Study:
- To compare the characteristic histologic differences between CAH-C and CAH-B.
- Identify specific histological features indicative of CAH-C.
Main Methods:
- Histologic analysis of liver biopsies from 19 CAH-C patients and 19 CAH-B patients.
- Utilized a modified Knodell's histologic activity index to score features like portal inflammation, necroinflammation, and fibrosis.
- Serological tests (EIA for HCV antibody, RIA for HBsAg) confirmed diagnoses.
Main Results:
- Follicular portal inflammation with prominent lymphocytes was more frequent in CAH-C (10/19) than CAH-B (5/19).
- Severe sinusoidal lymphocytic reactions were more prominent in CAH-C (11/19) compared to CAH-B (6/19).
- Periportal necroinflammation, fibrosis, focal necrosis, regeneration, and polyploid nuclear changes were more pronounced in CAH-B.
Conclusions:
- Follicular portal inflammation and severe sinusoidal lymphocytic reactions are common histologic findings in CAH-C.
- These features help differentiate CAH-C from CAH-B in serologically confirmed cases.