Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Hypoxic ventilatory response and hypoxic depression].

H Kimura1, M Niijima, H Edo

  • 1Department of Chest Medicine, Chiba University School of Medicine, Japan.

Nihon Kyobu Shikkan Gakkai Zasshi
|December 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Initial Experience of Operator-controlled Gating Technique Under Free Breathing During CT-guided Percutaneous Drainage of Postoperative Deep Upper Abdominal Fluid Collections.

Clinical radiology·2021
Same author

Manifestation of pulmonary hypertension during REM sleep in obstructive sleep apnea syndrome.

American journal of respiratory and critical care medicine·1999
Same author

Effects of chest wall vibration on breathlessness during hypercapnic ventilatory response.

Journal of applied physiology (Bethesda, Md. : 1985)·1998
Same author

Compensatory excretion of prostacyclin and thromboxane metabolites in obstructive sleep apnea syndrome.

Internal medicine (Tokyo, Japan)·1998
Same author

Control of upper airway function in response to hypoxia in patients with obstructive sleep apnea syndrome.

Internal medicine (Tokyo, Japan)·1998
Same author

[Nocturnal pulmonary hypertension in patients with obstructive sleep apnea associated with daytime pulmonary hypertension].

Nihon Kyobu Shikkan Gakkai zasshi·1998
Same journal

[A case of expanding pulmonary aspergilloma].

Nihon Kyobu Shikkan Gakkai zasshi·1998
Same journal

[A resected case of intralobar pulmonary sequestration with increased serum tumor markers, CA19-9, CA125 and NCC-ST-439].

Nihon Kyobu Shikkan Gakkai zasshi·1998
Same journal

[A case of allergic bronchopulmonary aspergillosis caused by Aspergillus terreus].

Nihon Kyobu Shikkan Gakkai zasshi·1998
Same journal

[Pulmonary thromboembolism associated with antiphospholipid syndrome in scleroderma].

Nihon Kyobu Shikkan Gakkai zasshi·1998
Same journal

[Clinical investigation of three cases of pulmonary eosinophilic granuloma].

Nihon Kyobu Shikkan Gakkai zasshi·1998
Same journal

[A case of primary acute pulmonary cavitation in sarcoidosis complicated by multiple nodular lesions in the central nervous system].

Nihon Kyobu Shikkan Gakkai zasshi·1998
See all related articles

Peripheral chemoreceptor (PCR) adaptation does not significantly contribute to hypoxic ventilatory depression (HVD). However, genioglossal muscle activity was notably reduced in sleep apnea patients during hypoxia.

Area of Science:

  • Respiratory Physiology
  • Neuroscience
  • Sleep Medicine

Background:

  • Hypoxic ventilatory depression (HVD) is a critical physiological response during sustained hypoxia.
  • Understanding the mechanisms of HVD is crucial for managing conditions like obstructive sleep apnea (OSA).

Purpose of the Study:

  • To investigate the role of peripheral chemoreceptor (PCR) adaptation in HVD during sustained hypoxia.
  • To assess the impact of HVD on diaphragm (DIA) and genioglossal (GG) muscle activity in healthy subjects and OSA patients.

Main Methods:

  • Sustained hypoxia (20 min) was applied to healthy subjects and OSA patients.
  • Peripheral chemoreceptor (PCR) function was assessed using a withdrawal test at 5 and 20 min.
  • Electromyography (EMG) of the diaphragm (EMGDIA) and genioglossal muscle (EMGGG) activity was recorded.

Related Experiment Videos

Main Results:

  • PCR adaptation did not appear to be a major contributor to HVD.
  • Minute ventilation and EMGDIA were suppressed similarly in both groups during HVD.
  • EMGGG was significantly and consistently attenuated in OSA patients, but not always in healthy subjects.

Conclusions:

  • HVD during sustained hypoxia is not primarily driven by PCR adaptation.
  • Impaired genioglossal muscle response to hypoxia is characteristic of OSA.
  • Central mechanisms may play a key role in regulating breathing and upper airway stability during hypoxic conditions, potentially improved by therapeutic interventions.