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[Hyperventilation syndrome].

K Chin1, M Ohi, K Kuno

  • 1Department of Clinical Physiology, Kyoto University, Japan.

Nihon Kyobu Shikkan Gakkai Zasshi
|December 1, 1992
PubMed
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Hypoxemia is common in hyperventilation syndrome (HVS) patients. Reduced breathing drive and dyspnea sensation under hypocapnia after hyperventilation may cause hypoxemia in HVS.

Area of Science:

  • Respiratory Physiology
  • Clinical Medicine

Background:

  • Hyperventilation syndrome (HVS) is associated with hypoxemic episodes in a significant number of patients.
  • The relationship between hypoxemia and the hypoxic ventilatory response (HVR) in HVS patients requires further investigation.

Purpose of the Study:

  • To investigate the link between hypoxemia and HVR in HVS patients.
  • To explore the mechanisms of hypoxemia development following acute hyperventilation in HVS.

Main Methods:

  • Examined HVR in HVS patients experiencing hypoxemic episodes.
  • Assessed minute ventilation and dyspnea (VAS scores) during HVR in normal subjects under isocapnia and hypocapnia following voluntary hyperventilation (VHV).

Main Results:

  • HVS patients with hypoxemia had a normal HVR.

Related Experiment Videos

  • In normal subjects, minute ventilation and dyspnea scores during HVR were higher under isocapnia than hypocapnia post-VHV.
  • HVR and dyspnea sensation were reduced under hypocapnia post-VHV.

    • Conclusions:

    • Reduced HVR and dyspnea sensation under hypocapnia following hyperventilation are implicated in the genesis of hypoxemia in HVS patients.
    • Hypoxemia is a clinically relevant sign in HVS.
    • Further research into breathing and chemical drive under hypocapnia is crucial for understanding respiratory regulation in HVS.