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Related Experiment Videos

Eucapnic hyperventilation-induced bronchoconstriction in rabbits.

S Koyama1, A Ohtsuka, T Horie

  • 1First Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.

The Tohoku Journal of Experimental Medicine
|December 1, 1992
PubMed
Summary
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Hyperventilation with dry air causes bronchoconstriction only in sensitized rabbits. Histamine plays a key role in this hyperventilation-induced bronchoconstriction (HIB) response in allergic rabbits.

Area of Science:

  • Respiratory Physiology
  • Allergy and Immunology

Background:

  • Hyperventilation challenges are used to assess airway reactivity.
  • The role of sensitization in hyperventilation-induced bronchoconstriction (HIB) is not fully understood.

Purpose of the Study:

  • To investigate if eucapnic hyperventilation with dry air induces bronchoconstriction in non-sensitized and ovalbumin-sensitized rabbits.
  • To explore the involvement of histamine in HIB in sensitized rabbits.

Main Methods:

  • Mechanical ventilation was used to perform eucapnic hyperventilation challenges with dry air and 5% CO2 in anesthetized rabbits.
  • Total lung resistance (RL) and dynamic compliance (Cdyn) were measured before and after the challenge.
  • The effect of an H1-receptor antagonist (chlorpheniramine) on HIB was assessed in sensitized rabbits.

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Main Results:

  • Non-sensitized rabbits showed no significant changes in RL or Cdyn.
  • Sensitized rabbits exhibited significant increases in RL and decreases in Cdyn post-hyperventilation.
  • Pretreatment with chlorpheniramine significantly suppressed the RL increase in sensitized rabbits.

Conclusions:

  • Eucapnic hyperventilation with dry air induces HIB exclusively in sensitized rabbits.
  • Histamine, acting via H1 receptors, plays a significant role in the development of HIB in sensitized individuals.