Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The interleukin network and lymphoid development.

G J Nossal1

  • 1Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia.

Growth Factors (Chur, Switzerland)
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clonal deletion in self-tolerance.

Immunology today·2014
Same author

The case history of Mr T.I. Terminal patient or still curable?

Immunology today·2014
Same author

A purgative mastery.

Nature·2001
Same author

The Global Alliance for Vaccines and Immunization--a millennial challenge.

Nature immunology·2001
Same author

The new biology and human reproduction.

The Australian & New Zealand journal of obstetrics & gynaecology·2001
Same author

Modern medicine and global communicable diseases: new partnerships for progress.

Australian and New Zealand journal of medicine·2000
Same journal

The role of the epidermal growth factor in the pathogenesis of schizophrenia. Clinical and diagnostic value.

Growth factors (Chur, Switzerland)·2026
Same journal

The role of ERK signaling pathway in pituitary adenomas: from molecular mechanisms to targeted therapy.

Growth factors (Chur, Switzerland)·2026
Same journal

Role of soluble EGFR, Fas, and Fas ligand in pelvic pain severity and their association with endometriosis in infertile woman: a case-control study.

Growth factors (Chur, Switzerland)·2026
Same journal

ErbB receptor stimulation is required for mouse Colon adenoma organoids to form crypts.

Growth factors (Chur, Switzerland)·2026
Same journal

Chorioallantoic membrane assay demonstrating pro-angiogenic properties of BRAF inhibitor: a tool to treat chronic wounds.

Growth factors (Chur, Switzerland)·2026
Same journal

Extracellular matrix biomarkers and transforming growth factor-β in hypertrophic cardiomyopathy: interaction between biomarkers.

Growth factors (Chur, Switzerland)·2026
See all related articles

Lymphoid organ development involves distinct antigen-independent and antigen-dependent processes. Cellular interactions are crucial for lymphocyte development in primary organs and immune responses in secondary lymphoid organs.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Lymphoid development follows distinct pathways in primary (thymus, bone marrow) and secondary lymphoid organs.
  • Primary lymphoid organs facilitate antigen-independent lymphocyte precursor development and selection.
  • Secondary lymphoid organs support antigen-driven lymphocyte proliferation and differentiation into effector cells.

Purpose of the Study:

  • To delineate the distinct cellular interactions and molecular requirements governing lymphocyte development in primary and secondary lymphoid organs.
  • To compare the in vitro mimicry of B cell versus T cell development.
  • To understand the regulatory roles of cell-cell interactions and cytokines in adaptive immunity.

Main Methods:

  • Review of existing literature on lymphoid organogenesis and lymphocyte differentiation.

Related Experiment Videos

  • Analysis of in vitro systems for studying B and T cell development.
  • Examination of the roles of cytokines and cellular interactions in immune cell maturation.

    • Main Results:

    • B cell development in vitro is more advanced than T cell development, with key roles for IL-7 and c-kit ligand (KL).
    • T cell development in the thymus is complex, with limited in vitro mimicry and no single critical interleukin identified.
    • Secondary lymphoid organ function relies on interactions between accessory cells, T cells, and B cells, with cytokines playing multifaceted regulatory roles.

    Conclusions:

    • Lymphocyte development is critically dependent on specific microenvironmental cues and cellular interactions within primary and secondary lymphoid organs.
    • Current in vitro systems partially recapitulate B cell development, but T cell development remains challenging to model.
    • Cytokine functions in immune regulation are complex and not easily compartmentalized into simple categories.