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Functional changes implicating dopaminergic systems following perinatal treatments.

T Archer1, A Fredriksson

  • 1Department of Psychology, University of Göteborg, Sweden.

Developmental Pharmacology and Therapeutics
|January 1, 1992
PubMed
Summary
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Perinatal exposure to metallic mercury, organic tin, and certain neuroleptics or antiemetics can alter offspring behavior and learning. These developmental neurotoxicants impact dopaminergic system development, affecting motor activity and maze performance.

Area of Science:

  • Neuroscience
  • Developmental Toxicology
  • Behavioral Pharmacology

Background:

  • Perinatal exposure to environmental toxicants can impact neurodevelopment.
  • Understanding the long-term behavioral consequences of such exposures is crucial for public health.
  • Dopaminergic pathways play a key role in motor control, learning, and reward.

Purpose of the Study:

  • To investigate the effects of various perinatal treatments on spontaneous and learned behaviors in rodents.
  • To assess the impact of metallic mercury, organic tin, neuroleptics, and antiemetics on behavioral development.
  • To explore potential alterations in dopaminergic system function following perinatal toxicant exposure.

Main Methods:

  • Rodents (rats and mice) received diverse perinatal treatments, including metallic mercury, organic tin, 6-hydroxydopamine (6-OHDA), metaclopramide, haloperidol, and remoxipride.

Related Experiment Videos

  • Offspring were assessed as adults using a battery of behavioral tests measuring spontaneous motor activity (locomotion, rearing, head dipping) and learning (radial arm maze, circular swim maze).
  • d-amphetamine-induced activity was measured to infer changes in dopaminergic pathway function.

    • Main Results:

    • Prenatal exposure to metallic mercury, organic tin, haloperidol, and remoxipride altered spontaneous motor activity and impaired radial arm maze learning.
    • Postnatal exposure to metallic mercury, 6-OHDA, and metaclopramide also affected spontaneous activity and radial arm maze performance.
    • Most treatments did not affect circular swim maze performance, except for high-dose 6-OHDA, which caused significant impairments.

    Conclusions:

    • Perinatal exposure to metallic mercury, organic tin, and certain neuroleptics/antiemetics can lead to significant alterations in behavioral development.
    • These exposures appear to impact the functional development of dopaminergic systems, even in the absence of overt neurochemical changes.
    • The findings highlight the vulnerability of the developing nervous system to environmental toxicants and their long-term behavioral consequences.