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Stress and the immune system.

R L Speirs1

  • 1Royal College of Surgeons, London.

Dental Update
|November 1, 1992
PubMed
Summary

Stress impacts susceptibility to disease. Emerging science, psychoneuroendocrinimmunology, reveals how stressors activate the neuroendocrine axis, influencing the immune system bidirectionally and affecting behavior.

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Area of Science:

  • Psychoneuroendocrinimmunology
  • Neuroimmunology
  • Stress Physiology

Background:

  • The long-held notion linking stress and disease susceptibility is now scientifically validated.
  • The field of psychoneuroimmunology, now expanded to psychoneuroendocrinimmunology, is rapidly growing.

Purpose of the Study:

  • To examine the complex interactions between stress, the neuroendocrine system, and the immune system.
  • To provide an overview of the emerging field of psychoneuroendocrinimmunology.

Main Methods:

  • Review of existing literature on stress response pathways.
  • Examination of the bidirectional communication between the neuroendocrine and immune systems.
  • Analysis of how immune cell signaling affects nervous and endocrine functions.

Main Results:

  • Stressors activate the neuroendocrine axis, which modulates immune system function.
  • Immune cells release signaling molecules that impact the endocrine and nervous systems.
  • These interactions influence physiological responses and behavior.

Conclusions:

  • Psychoneuroendocrinimmunology elucidates the intricate connections between psychological stress and physical health.
  • Understanding these bidirectional pathways is crucial for comprehending disease susceptibility and developing interventions.

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