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Related Experiment Videos

Auditory brainstem responses in term neonates treated with gentamicin.

C H Tsai1, F J Tsai

  • 1Department of Pediatrics, China Medical College Hospital, Taichung, Taiwan.

Zhonghua Minguo Xiao Er Ke Yi Xue Hui Za Zhi [Journal]. Zhonghua Minguo Xiao Er Ke Yi Xue Hui
|November 1, 1992
PubMed
Summary

Short-term gentamicin treatment in newborns may temporarily affect auditory brainstem responses. These auditory pathway changes, specifically prolonged latencies, resolved by the tenth day of life.

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Area of Science:

  • Neonatal Medicine
  • Audiology
  • Pharmacology

Background:

  • Gentamicin is frequently used for neonatal infections.
  • The effects of prophylactic gentamicin on auditory development are not fully understood.
  • Auditory brainstem responses (ABR) are crucial for assessing auditory pathway function in infants.

Purpose of the Study:

  • To investigate the transient effects of early-life gentamicin prophylaxis on auditory brainstem responses in healthy neonates.
  • To determine the relationship between gentamicin concentration and ABR alterations.

Main Methods:

  • Seventeen infants receiving gentamicin prophylaxis were compared to 27 healthy, weight-matched controls.
  • Auditory brainstem responses were assessed on the 3rd and 10th day of life.

Related Experiment Videos

  • Peak and trough gentamicin levels were correlated with ABR latencies.

    • Main Results:

    • Gentamicin-treated infants showed significantly prolonged latencies in ABR components (V, I-V, III-V) compared to controls.
    • These prolonged latencies normalized by the 10th day of life.
    • Higher gentamicin concentrations correlated with increased III-V interval latency.

    Conclusions:

    • Short-course gentamicin prophylaxis can transiently alter central auditory pathway transmission in neonates.
    • ABR monitoring may be valuable in assessing the impact of gentamicin.
    • Findings suggest careful consideration of gentamicin use even for prophylaxis in healthy infants.