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[Immune complex in the wall of the gallbladder in patients with cholelithiasis: deposition and its pathological

Y Yang1

  • 1Nanfang Hospital, Guangzhou.

Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery]
|November 1, 1992
PubMed

The gallbladder specimens from 53 patients with cholelithiasis were studied by immunohistochemical method. Deposition of immune complex (IC) was observed on the mucosal and glandular epithelium in 84% of patients with gallstones and 47% of patients with choledocholithiasis. IgG and C3 were the most frequent complement component demonstrated at the site of IC deposition, but Clq, factor B and C4 were also present in many cases, suggesting the local complement activation. We conclude that IC may play a pathogenetic role in the injury of the mucosa and tissue of gallbladder in patients with cholelithiasis.

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