[Effects of shock and reperfusion on multiple organ function after gunshot wounds]

The effects of shock and reperfusion on multiple organ function in gunshot canine model were studied. The results showed that organ function damage even failure of the lung, liver and kidney occurred 24 hours after wound. In some dogs bacterial translocation and increase of lipid peroxidation (LPO) were also found. The experimental findings suggested that the activated free radical system and bacterial translocation may be the underlying pathogenesis of multiple organ injuries and failure. It is possible to establish a model for studying multiple organ failure on this experimental condition.