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Changing profile of enteric fever--in summer-91

S Gupta1, H S Meena

  • 1Department of Medicine, Lady Hardinge Medical College, New Delhi.

The Journal of the Association of Physicians of India
|November 1, 1992
PubMed

Insights

This study on enteric fever found that amikacin, ciprofloxacin, and ofloxacin showed 100% in vitro sensitivity. These antibiotics were highly effective in treating patients, with fever subsiding in 3-5 days.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Clinical Medicine

Background:

  • Enteric fever remains a significant global health concern.
  • Understanding clinical presentations and antimicrobial resistance is crucial for effective management.

Purpose of the Study:

  • To analyze the clinical features, complications, and antimicrobial sensitivity patterns of enteric fever.
  • To evaluate the efficacy of specific antibiotics in treating enteric fever.

Main Methods:

  • A study of 30 patients diagnosed with enteric fever.
  • Clinical data collection including presenting symptoms and complications.
  • In vitro antimicrobial sensitivity testing of isolated organisms.
  • Assessment of clinical response to antibiotic treatment.

Main Results:

  • Fever was the predominant symptom in all cases.
  • Common complications included myocarditis, paralytic ileus, pneumonia, and joint effusion.
  • Amikacin, ciprofloxacin, and ofloxacin demonstrated 100% in vitro sensitivity.
  • Ofloxacin and ciprofloxacin achieved a 100% clinical response rate, with fever resolution in 3-5 days.

Conclusions:

  • Ciprofloxacin and ofloxacin are highly effective treatments for enteric fever, exhibiting excellent clinical response rates.
  • Antimicrobial stewardship is essential given varying sensitivities to older antibiotics like chloramphenicol and ampicillin.

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