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Related Experiment Videos

[Left ventricular diastolic function in apical hypertrophic cardiomyopathy].

T Yamakado1, T Hayashi, S Ohkubo

  • 1First Department of Internal Medicine, Mie University School of Medicine, Tsu.

Journal of Cardiology
|January 1, 1992
PubMed
Summary

Apical hypertrophic cardiomyopathy (AHCM) shows impaired left ventricular (LV) relaxation and reduced diastolic distensibility, similar to non-obstructive HCM. Early diastolic filling remains preserved in AHCM patients.

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Area of Science:

  • Cardiology
  • Cardiovascular Physiology
  • Medical Imaging

Context:

  • Apical hypertrophic cardiomyopathy (AHCM) is a distinct form of HCM.
  • Patients with AHCM often present with characteristic ECG and angiographic findings.
  • Understanding diastolic dysfunction in AHCM is crucial for patient management.

Purpose:

  • To assess left ventricular (LV) diastolic function in patients with AHCM.
  • To compare diastolic parameters between AHCM, non-obstructive HCM (HNCM), and normal controls.
  • To investigate the relationship between LV diastolic properties and specific clinical features in AHCM.

Summary:

  • LV cineangiograms and pressures were analyzed in 11 AHCM patients, 10 HNCM patients, and 10 controls.
  • LV isovolumic relaxation time constant (T) was prolonged, and diastolic pressure-volume relations were shifted upwards in both AHCM and HNCM groups compared to controls.

Related Experiment Videos

  • Despite impaired relaxation and distensibility, LV early diastolic filling, assessed by peak filling rate (PFR), was preserved in AHCM.

    • Impact:

    • The study reveals that impaired LV diastolic function, characterized by prolonged isovolumic relaxation and reduced distensibility, is a feature of AHCM.
    • These findings suggest that diastolic dysfunction in AHCM may share mechanisms with HNCM.
    • Preserved early diastolic filling in AHCM warrants further investigation into compensatory mechanisms and clinical implications.