[Early afterdepolarization and cesium chloride induced ventricular arrhythmias]

This study is to demonstrate the role of early afterdepolarization (EAD) in the cesium chloride induced long QT interval and ventricular arrhythmias by recording monophasic action potential (MAP) of right ventricular endocardium with contact electrode in 12 closed chest dogs. The results suggested that EAD could produce triggered premature ventricular beats and ventricular tachycardias (VT) in situ. The first ectopic ventricular beat of EAD induced VT usually appears close to the peak of the U wave. Short-long-short interval sequence preceding episodes of VT occurred in 89.6% of VT.