Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cellular thermogenesis.

J Himms-Hagen

    Annual Review of Physiology
    |January 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Cellular thermogenesis involves multiple mechanisms, not a single one. Further research is needed to fully understand the complex regulation of heat production and mitochondrial function.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Sympathetic and sensory nerves in control of growth of brown adipose tissue: Effects of denervation and of capsaicin.

    Neurochemistry international·2010
    Same author

    Exercise in a pill: feasibility of energy expenditure targets.

    Current drug targets. CNS and neurological disorders·2004
    Same author

    Does brown adipose tissue (BAT) have a role in the physiology or treatment of human obesity?

    Reviews in endocrine & metabolic disorders·2001
    Same author

    Sim1 haploinsufficiency causes hyperphagia, obesity and reduction of the paraventricular nucleus of the hypothalamus.

    Human molecular genetics·2001
    Same author

    Physiological role of UCP3 may be export of fatty acids from mitochondria when fatty acid oxidation predominates: an hypothesis.

    Experimental biology and medicine (Maywood, N.J.)·2001
    Same author

    Overexpression of UCP-3 in skeletal muscle of mice results in increased expression of mitochondrial thioesterase mRNA.

    Biochemical and biophysical research communications·2001

    Area of Science:

    • Biochemistry
    • Cellular Biology
    • Physiology

    Background:

    • Cellular thermogenesis, the process of heat production in cells, is crucial for maintaining body temperature and energy balance.
    • Altered cellular thermogenesis is implicated in various physiological and pathological conditions, including hyperthyroidism, cold acclimation, exercise, and metabolic syndromes.

    Purpose of the Study:

    • To review and synthesize current knowledge on the mechanisms underlying basal and altered cellular thermogenesis.
    • To identify gaps in understanding and areas requiring further investigation into the complex regulatory networks involved.

    Main Methods:

    • This is a review article, synthesizing existing research and literature.
    • Analysis of studies investigating cellular heat production, mitochondrial function, and their regulation.

    Related Experiment Videos

    Main Results:

    • No single mechanism explains all instances of cellular thermogenesis; multiple pathways contribute.
    • Increased sodium-potassium pump activity and mitochondrial uncoupling are identified as potential contributors.
    • Various cellular factors, including ions, fatty acids, and signaling molecules, are involved in regulating mitochondrial oxidations.

    Conclusions:

    • Cellular thermogenesis is a multifactorial process requiring a comprehensive understanding of interacting regulatory mechanisms.
    • Further research is essential to elucidate the precise roles of specific factors and tissue-specific differences in mitochondrial regulation.
    • Understanding mitochondrial biogenesis is key to explaining adaptations in thermogenesis related to various physiological states and metabolic disorders.