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[Telesystolic mitral insufficiency with systolic click, mitral valve prolapse, and hypertrophic obstructive
Insights
Abnormal left ventricular contraction can cause late systolic murmurs and mid-systolic clicks. This study found cardiomyopathy with patchy hypertrophy can lead to intraventricular obstruction, contributing to this syndrome.
Area of Science:
- Cardiology
- Cardiac Physiology
Context:
- The syndrome of late systolic murmur and mid-systolic click, often associated with mitral valve prolapse, has diverse etiologies.
- Recent research highlights the role of left ventricular (LV) contraction abnormalities in this condition.
Purpose:
- To investigate the role of left ventricular contraction abnormalities in patients presenting with late systolic murmur and mid-systolic click.
- To elucidate the underlying mechanisms, including cardiomyopathy and intraventricular obstruction.
Summary:
- Seven cases were evaluated using phonomechanocardiography, cineangiography, and hemodynamic assessments.
- Findings indicate that left ventricular contraction abnormalities, stemming from cardiomyopathy with patchy hypertrophy, can cause left intraventricular obstruction.
- This obstruction contributes to the characteristic murmur and click syndrome.
Impact:
- Provides a deeper understanding of the pathophysiology of late systolic murmur and mid-systolic click syndrome.
- Highlights cardiomyopathy and intraventricular obstruction as significant contributing factors.
- Informs diagnostic and therapeutic strategies for patients with this valvular heart condition.
Abstract:
There are several causes of the syndrome of "Late systolic murmur and mid-systolic click" due to mitral incompetence with ballooning of the valve, and, as numerous recent publications have shown, amongst them must be included abnormalities of left ventricular contraction. Seven cases have been studied by phonomechanocardiographic, cineangiographic, and haemodynamic methods, and analysis of the findings has shown that the abnormalities of contraction may be due to a cardiomyopathy, with a variable degree of left ventricular hypertrophy which is usually of patchy distribution, and leads to a certain degree of left intraventricular obstruction.