Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Experimental Chagas' disease in dogs.

M de Lana¹, E Chiari, W L Tafuri

¹Departamento de Análises Clínicas, Escola de Farmácia, Universidade Federal de Ouro Preto, MG, Brasil.

Memorias Do Instituto Oswaldo Cruz

|January 1, 1992

Summary

This study shows dogs can develop experimental Chagas' disease, mimicking human infections. The Be-78 Trypanosoma cruzi strain reliably caused chronic cardiac disease in dogs, validating them as a key research model.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Interactions between Tax of HTLV1 and cellular factors].

Virologie (Montrouge, France)·2023

Same author

Immunoproteomic and bioinformatic approaches to identify secreted Leishmania amazonensis, L. braziliensis, and L. infantum proteins with specific reactivity using canine serum.

Veterinary parasitology·2016

Same author

Glycol methacrylate embedding for the histochemical study of the gastrointestinal tract of dogs naturally infected with Leishmania infantum.

European journal of histochemistry : EJH·2015

Same author

Reducing surgical site infection in lumbar surgery? What is the comparative effectiveness data?

Journal of neurosurgical sciences·2014

Same author

Mitral valve prolapse and conduction disturbances: the forgotten association.

Cardiovascular journal of Africa·2010

Same author

Humoral immunological profile and parasitological statuses of Leishmune vaccinated and visceral leishmaniasis infected dogs from an endemic area.

Veterinary parasitology·2010

Area of Science:

Veterinary Medicine
Infectious Diseases
Parasitology

Background:

Chagas' disease, caused by Trypanosoma cruzi, significantly impacts human health.
Developing reliable animal models is crucial for understanding and treating Chagas' disease.

Purpose of the Study:

To evaluate the dog as an experimental model for Chagas' disease.
To reproduce the acute and chronic phases of human Chagas' disease, particularly cardiac manifestations.

Main Methods:

Inoculation of 64 dogs with two different Trypanosoma cruzi strains (Be-62 and Be-78).
Infection routes included blood trypomastigotes and metacyclic trypomastigotes via conjunctival route.
Monitoring of parasitemia, clinical signs, serology (IgM, IgG), electrocardiograms, hemograms, and post-mortem histopathology.

Main Results:

Successful reproduction of acute and chronic Chagas' disease, including cardiac forms.
The Be-78 strain consistently induced diffuse fibrosing chronic chagasic cardiopathy in dogs.
The canine model exhibited parasitemia, clinical, serological, and pathological patterns similar to human infections.

Conclusions:

Dogs serve as a suitable and reproducible experimental model for studying Chagas' disease, meeting WHO criteria.
The canine model facilitates research into the pathogenesis and potential treatments of Chagas' disease, especially chronic cardiac complications.
The ease of handling and availability of dogs further support their utility in experimental settings.

Related Experiment Videos