Related Experiment Video
Updated: Aug 14, 2026
08:35
Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding
Published on: February 26, 2015
[Attempts at reconstitution of skin continuity]
1Oddział Chirurgii Plastycznej Centrum Medycznego Uniwersytetu Kalifornijskiego, San Diego.
Postepy Higieny I Medycyny Doswiadczalnej
|January 1, 1992
Summary
This review covers the biological and clinical aspects of creating and using living skin equivalents. It details various models using either the patient
Area of Science:
- Regenerative Medicine
- Tissue Engineering
- Dermatology
Context:
- Living skin equivalents (LSEs) are advanced biomaterials used in skin reconstruction.
- Understanding LSE preparation and application is crucial for clinical success.
- Both autogenic (patient's own cells) and allogenic (donor cells) sources are utilized.
Purpose:
- To review the fundamental biological and clinical principles governing the preparation and application of LSEs.
- To describe diverse models of LSEs, highlighting their construction and cellular origins.
- To provide a comprehensive overview for researchers and clinicians in the field of skin tissue engineering.
Summary:
- The review synthesizes current knowledge on LSEs, encompassing their biological basis and clinical utility.
- It details various LSE models, differentiating between those derived from autogenic and allogenic sources.
- Key preparation techniques and application strategies are discussed.
Impact:
- Facilitates informed decision-making in selecting and utilizing LSEs for various dermatological conditions.
- Contributes to the advancement of regenerative therapies for skin defects.
- Supports the development of standardized protocols for LSE production and clinical implementation.
