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[Candidiasis in AIDS patients].

C E Campos1, R P Igreja, E P Campos

  • 1Depto. de Microbiologia e Imunologia, Universidade Estadual Paulista, Botucatu, SP, Brasil.

Revista Da Sociedade Brasileira De Medicina Tropical
|July 1, 1992
PubMed
Summary

Digestive candidiasis in AIDS patients showed high resistance to azoles and nystatin. Candida albicans was the predominant species, with prior antifungal therapy potentially increasing drug resistance.

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Area of Science:

  • Mycology
  • Infectious Diseases
  • Immunocompromised Hosts

Background:

  • Digestive candidiasis is a common opportunistic infection in patients with Acquired Immunodeficiency Syndrome (AIDS).
  • Understanding antifungal susceptibility patterns is crucial for effective treatment of candidiasis in this population.

Purpose of the Study:

  • To evaluate the antifungal susceptibility of Candida strains isolated from AIDS patients with digestive candidiasis.
  • To determine the proportion of Candida albicans and its susceptibility to various antifungal agents.

Main Methods:

  • Agar Sabouraud culture and germ tube tests were used for Candida species identification.
  • Minimum Inhibitory Concentration (MIC50) assays were performed for azoles, polyenes, and 5-fluorocytosine.
  • Siegel tests assessed Candida albicans proportions in isolated strains.

Main Results:

  • Candida albicans was identified in 80% of the 35 strains isolated from AIDS patients.
  • High MIC50 values were observed for azoles (ketoconazole, itraconazole, fluconazole) and nystatin.
  • Amphotericin B showed the lowest MIC50 (0.12 µg/ml), while 5-fluorocytosine also demonstrated good activity (1.6 µg/ml).

Conclusions:

  • Candidiasis in AIDS patients frequently involves Candida albicans with high MIC50 to azoles and nystatin.
  • Previous antifungal therapy may contribute to increased MIC50 values in Candida strains.
  • Amphotericin B therapy did not significantly influence early or late mortality in the studied patients.

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