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[Candidiasis in AIDS patients].

C E Campos1, R P Igreja, E P Campos

  • 1Depto. de Microbiologia e Imunologia, Universidade Estadual Paulista, Botucatu, SP, Brasil.

Revista Da Sociedade Brasileira De Medicina Tropical
|July 1, 1992
PubMed
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Digestive candidiasis in AIDS patients showed high resistance to azoles and nystatin. Candida albicans was the predominant species, with prior antifungal therapy potentially increasing drug resistance.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Immunocompromised Hosts

Background:

  • Digestive candidiasis is a common opportunistic infection in patients with Acquired Immunodeficiency Syndrome (AIDS).
  • Understanding antifungal susceptibility patterns is crucial for effective treatment of candidiasis in this population.

Purpose of the Study:

  • To evaluate the antifungal susceptibility of Candida strains isolated from AIDS patients with digestive candidiasis.
  • To determine the proportion of Candida albicans and its susceptibility to various antifungal agents.

Main Methods:

  • Agar Sabouraud culture and germ tube tests were used for Candida species identification.
  • Minimum Inhibitory Concentration (MIC50) assays were performed for azoles, polyenes, and 5-fluorocytosine.
  • Siegel tests assessed Candida albicans proportions in isolated strains.

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Main Results:

  • Candida albicans was identified in 80% of the 35 strains isolated from AIDS patients.
  • High MIC50 values were observed for azoles (ketoconazole, itraconazole, fluconazole) and nystatin.
  • Amphotericin B showed the lowest MIC50 (0.12 µg/ml), while 5-fluorocytosine also demonstrated good activity (1.6 µg/ml).

Conclusions:

  • Candidiasis in AIDS patients frequently involves Candida albicans with high MIC50 to azoles and nystatin.
  • Previous antifungal therapy may contribute to increased MIC50 values in Candida strains.
  • Amphotericin B therapy did not significantly influence early or late mortality in the studied patients.