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The influenza virus: its morphology, immunology, and kinetics of multiplication

P von MAGNUS

    Bulletin of the World Health Organization
    |January 1, 1953
    PubMed

    Insights

    This study details influenza virus morphology, antigenic variations in influenza A and B strains, and virus multiplication kinetics. Understanding these aspects is crucial for developing effective antiviral therapies.

    Area of Science:

    • Virology
    • Immunology
    • Microbiology

    Background:

    • Influenza virus exhibits diverse morphologies, including spherical and filamentous forms, with unclear relationships.
    • Antigenic variations in influenza A and B viruses have been observed over two decades.
    • Serological behaviors like non-specific inhibition and avidity effects are noted.

    Purpose of the Study:

    • To describe the morphology and components of the influenza virus.
    • To discuss the antigenic constitution and variations of influenza A and B viruses.
    • To review experimental investigations on influenza virus multiplication kinetics and their implications for treatment.

    Main Methods:

    • Morphological characterization of influenza virus components.
    • Analysis of antigenic patterns and serological behaviors of influenza strains.
    • Experimental studies on virus multiplication kinetics in animal hosts, considering factors like temperature and seed virus concentration.

    Main Results:

    • Differentiation of elementary body and soluble substance properties.
    • Description of antigenic variations and serological differences in influenza viruses.
    • Review of factors influencing influenza virus multiplication and host-cell interactions.

    Conclusions:

    • Filamentous structures may represent a form or multiplication stage of the virus.
    • Understanding antigenic variations and multiplication kinetics is key to controlling influenza.
    • Enzymatic virus/host-cell interactions offer insights into chemotherapeutic strategies for influenza.
    Keywords:
    INFLUENZA VIRUSES

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