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Related Experiment Videos

Adrenergic receptor function in fat cells.

P Arner1

  • 1Department of Medicine, Huddinge Hospital, Karolinska Institute, Stockholm.

The American Journal of Clinical Nutrition
|January 1, 1992
PubMed
Summary

Fat cells express various adrenoceptors, with beta 1 adrenoceptors found in all types. Adrenoceptor function is highly regulated and may influence regional obesity development.

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Area of Science:

  • Adipose tissue biology
  • Endocrinology
  • Molecular pharmacology

Background:

  • Classical adrenoceptor subtypes are functionally expressed in adipocytes.
  • Beta 1 adrenoceptors are ubiquitously present across all fat cell types.
  • Significant adrenoceptor reserve exists, with ~50% of beta and alpha 2 adrenoceptors being spare.

Purpose of the Study:

  • To investigate the regulation and expression of adrenoceptors in fat cells.
  • To explore the role of adrenoceptors in the development of regional obesity.

Main Methods:

  • Functional expression analysis of adrenoceptor subtypes in fat cells.
  • Investigation of adrenoceptor regulation by hormones and physiological factors.
  • Assessment of adrenoceptor desensitization and site-specific variations.

Main Results:

  • Beta adrenoceptors are extensively regulated by insulin, sex hormones, thyroid hormones, and various physiological conditions.
  • Alpha 2 adrenoceptors show developmental alterations in infancy and decreased expression during fasting.
  • Beta adrenoceptors, unlike alpha 2, undergo homologous desensitization; site variations in receptor expression may contribute to regional obesity.

Conclusions:

  • Adrenoceptor expression and function in fat cells are dynamic and subject to significant regulation.
  • Variations in beta and alpha 2 adrenoceptor expression and function may play a role in the pathogenesis of regional obesity.

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