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Lactic acidosis in critical illness.

B A Mizock1, J L Falk

  • 1Department of Medicine, Chicago Medical School, IL.

Critical Care Medicine
|January 1, 1992
PubMed
Summary

Lactic acidosis in critically ill patients indicates oxygen debt and impacts survival. Monitoring lactate levels aids resuscitation, while therapies focus on improving oxygen delivery to reduce tissue hypoxia.

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Area of Science:

  • Critical Care Medicine
  • Biochemistry
  • Physiology

Background:

  • Lactic acidosis is a critical condition in intensive care.
  • Understanding lactate metabolism is key to managing critically ill patients.
  • Lactate serves as a crucial metabolic indicator of shock.

Purpose of the Study:

  • To review current knowledge on lactic acidosis in critically ill patients.
  • To examine lactate's role as a shock monitor.
  • To review therapeutic strategies for lactic acidosis.

Main Methods:

  • Comprehensive literature review.
  • Inclusion of basic science, medical, surgical, and critical care studies.

Main Results:

  • Lactic acidosis severity correlates with oxygen debt and survival.
  • Lactate monitoring can guide resuscitation efforts.
  • Therapies aim to maximize oxygen delivery and reduce hypoxia.

Conclusions:

  • Lactate levels are a prognostic indicator in critical illness.
  • Optimizing oxygen delivery is central to managing lactic acidosis.
  • The efficacy of buffering agents and other specific therapies is not definitively proven.

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