Related Experiment Video

Updated: Sep 18, 2026

A Model for Epilepsy of Infectious Etiology using Theiler's Murine Encephalomyelitis Virus
05:33

A Model for Epilepsy of Infectious Etiology using Theiler's Murine Encephalomyelitis Virus

Published on: June 23, 2022

Western equine encephalitis in infants; a report on three cases with sequelae

H B BRUYN, E H LENNETTE

    California Medicine
    |November 1, 1953
    PubMed

    Insights

    Western equine encephalitis virus frequently affects children. This study details three infant infections, highlighting diagnostic challenges and sequelae in young children with central nervous system infections.

    Area of Science:

    • Pediatric Neurology
    • Virology
    • Infectious Diseases

    Background:

    • Western equine encephalitis (WEE) is a significant cause of encephalitis in children.
    • Approximately one-third of laboratory-confirmed WEE cases occur in children under 10 years old.

    Purpose of the Study:

    • To describe WEE virus infections in infants under one year of age.
    • To discuss diagnostic challenges of central nervous system disturbances in infants.
    • To emphasize WEE virus as a potential cause of acute CNS infections and neurological sequelae in children.

    Main Methods:

    • Case series describing three infants with WEE virus infection.
    • Discussion of diagnostic difficulties in pediatric central nervous system infections.

    Main Results:

    • Three cases of Western equine encephalomyelitis virus infection in infants under one year of age are presented.
    • Resultant sequelae from WEE virus infection in these infants are detailed.
    • Difficulties in diagnosing central nervous system disturbances in very young children are highlighted.

    Conclusions:

    • Arthropod-borne encephalitis viruses, including WEE virus, should be considered in the etiology of acute central nervous system infections in childhood.
    • These viruses may be responsible for obscure, severe neurological disturbances in pediatric populations.
    • Early consideration of WEE virus is crucial for timely diagnosis and management in infants and children.

    Keywords:
    ENCEPHALOMYELITIS, EQUINE/in infant and child

    More Related Videos

    Amplitude-Integrated EEG in Infants at Risk of Hypoxic-Ischemic Encephalopathy: A Feasibility Study in Road and Air Transport in Western Australia05:15

    Amplitude-Integrated EEG in Infants at Risk of Hypoxic-Ischemic Encephalopathy: A Feasibility Study in Road and Air Transport in Western Australia

    Published on: June 21, 2024

    The Adjuvant Efficacy of Angong Niuhuang Pill in the Treatment of Viral Encephalitis: A Meta-Analysis of Randomized Controlled Trials08:36

    The Adjuvant Efficacy of Angong Niuhuang Pill in the Treatment of Viral Encephalitis: A Meta-Analysis of Randomized Controlled Trials

    Published on: April 19, 2024

    Related Concept Videos

    Encephalitis l: Introduction01:19

    Encephalitis l: Introduction

    Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
    Encephalitis ll: Pathophysiology01:26

    Encephalitis ll: Pathophysiology

    Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
    Arboviral Encephalitis01:25

    Arboviral Encephalitis

    Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
    Viral Meningitis01:18

    Viral Meningitis

    Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
    Rocky Mountain Spotted Fever01:26

    Rocky Mountain Spotted Fever

    Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
    Cryptococcal Meningitis01:27

    Cryptococcal Meningitis

    Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...