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Simian virus 40 (SV40) small t antigen inhibits SV40 DNA replication in vitro
M Carbone1, J Hauser, M P Carty
1Section on Viruses and Cellular Biology, National Institute of Child Health and Human Development, Bethesda, Maryland 20892.
Journal of Virology
|March 1, 1992
Abstract:
We describe a biochemical function of simian virus 40 small t antigen, the inhibition of simian virus 40 large T antigen-mediated viral DNA replication in an in vitro replication system. Our results suggest that in this system, small t antigen prevents protein phosphatase 2A-mediated activation of large T antigen.