Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Lithium chloride and immunomodulation in taste aversion conditioning.

M Gauci¹, D F Bull, M Schedlowski

¹Faculty of Medicine, University of Newcastle, NSW, Australia.

Physiology & Behavior

|January 1, 1992

Summary

Lithium chloride (LiCl) is not immunologically neutral, contrary to previous assumptions. Its use in taste aversion studies may interfere with conditioned immunosuppression, requiring reevaluation of related research findings.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Hypothalamic pituitary adrenal axis hormone changes during IL-17A inhibition with secukinumab in patients with psoriasis.

Clinical immunology (Orlando, Fla.)·2025

Same author

Reliability of Hip Strength Assessment in Young Active People with Hip Dysplasia: An Examination in Student Circus Artists.

Medical problems of performing artists·2024

Same author

Association between hip muscle strength/function and hip cartilage defects in sub-elite football players with hip/groin pain.

Osteoarthritis and cartilage·2024

Same author

The association between hip/groin pain and hip strength in football players: An exploratory analysis of the FORCe cohort.

Journal of science and medicine in sport·2023

Same author

[Conditioning of the immune system-Already clinically usable?]

Zeitschrift fur Rheumatologie·2023

Same author

The association between statistical shape modeling-defined hip morphology and features of early hip osteoarthritis in young adult football players: Data from the femoroacetabular impingement and hip osteoarthritis cohort (FORCe) study.

Osteoarthritis and cartilage open·2022

Area of Science:

Neuroscience
Immunology
Behavioral Science

Background:

Lithium chloride (LiCl) is commonly used in taste aversion conditioning studies.
It has often been assumed to be immunologically neutral in these experiments.
This assumption is critical for studies investigating conditioning's effects on immunity.

Purpose of the Study:

To investigate the immunological neutrality of LiCl in taste aversion conditioning.
To determine if LiCl affects conditioned immunosuppression.
To reevaluate conclusions from studies using LiCl in behavioral immunomodulation research.

Main Methods:

Studies involving taste aversion conditioning.
Administration of LiCl as a unconditioned stimulus (UCS) or part of it.

Related Experiment Videos

Assessment of conditioned stimulus (CS) reexposure effects on immunosuppression.

Main Results:

LiCl demonstrated non-neutral immunological properties.
LiCl antagonized residual immunosuppression after initial UCS administration.
LiCl also antagonized conditioned immunosuppression following CS reexposure.

Conclusions:

The assumption of LiCl's immunological neutrality is incorrect.
LiCl can interfere with and antagonize conditioned immunosuppression effects.
Findings from studies using LiCl in behavioral immunomodulation may need reevaluation.