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Enhanced sensitivity to oxidative stress in Cu,ZnSOD depleted rat erythrocytes
G M Bartoli1, P Palozza, E Piccioni
1Department of Biology, University of Tor Vergata, Rome, Italy.
Biochimica Et Biophysica Acta
|February 12, 1992
Abstract:
The effects on red blood cells of superoxide dismutase (Cu,ZnSOD) depletion, induced by feeding Wistar rats with a copper deficient diet, were investigated. SOD depleted red blood cells were more sensitive to peroxidation and to hemolysis than normal cells when exposed to tert-butylhydroperoxide (t-BOOH). Membranes isolated from SOD depleted cells showed a lower content of vitamin E and higher (Na+, K+) and Mg2+ ATPase activities. These results support the view that superoxide dismutase plays an important role in cellular oxidative metabolism.