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Interleukin 1 and its relationship to endotoxin tolerance
1Department of Surgery, University of Pennsylvania, Philadelphia.
Archives of Surgery (Chicago, Ill. : 1960)
|February 1, 1992
Summary
Interleukin-1 (IL-1) pretreatment enhances antimicrobial activity and survival against endotoxin challenges, offering protection similar to lipopolysaccharide (LPS) tolerance.
Area of Science:
- Immunology
- Microbiology
- Pathogenesis of Sepsis
Background:
- Endotoxin (lipopolysaccharide [LPS])-induced cytokine release is key in sepsis.
- Sublethal LPS doses can induce tolerance to septic insults.
Purpose of the Study:
- To evaluate interleukin-1 (IL-1) pretreatment against LPS challenge.
- To examine IL-1's relationship to endotoxin tolerance.
Main Methods:
- Mice were pretreated with phosphate-buffered saline, IL-1, or LPS for 3 days.
- Macrophage antimicrobial activity, serum cytokine levels, and survival were assessed after an LPS challenge.
Main Results:
- IL-1 and LPS pretreatment increased macrophage antimicrobial activity and survival.
- Interleukin-6 levels decreased in IL-1 and LPS groups.
- Tumor necrosis factor levels decreased only in the LPS group.
Conclusions:
- IL-1 or low-dose LPS pretreatment may protect against sepsis by increasing antimicrobial activity and decreasing interleukin-6.
- IL-1 pretreatment confers endotoxin protection via a mechanism distinct from tumor necrosis factor tolerance.