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Relapsing and remitting human immunodeficiency virus-associated leukoencephalomyelopathy
J R Berger1, C Tornatore, E O Major
1Department of Neurology, University of Miami School of Medicine, FL 33151.
Annals of Neurology
|January 1, 1992
Abstract:
We describe a 33-year-old homosexual man with a steroid-responsive, remitting and relapsing leukoencephalopathy associated with recent human immunodeficiency virus type 1 (HIV-1) seroconversion. Biopsy of a parieto-occipital lesion revealed demyelination and astrogliosis with focal necrosis. Detailed investigations demonstrated no pathogens in the brain other than HIV-1. This patient illustrates that a neurological disorder clinically indistinguishable from multiple sclerosis may be the presenting manifestation of HIV-1 infection and may occur in the absence of clinically significant immunosuppression.