[Effect of lipiodol-cisplatinum arterial infusion chemotherapy on cellular immunity]

¹Dept. of Surgery, Kusatsu Branch Hospital, Gunma University School of Medicine, Japan.

Gan to Kagaku Ryoho. Cancer & Chemotherapy

|March 1, 1992

Abstract:

A Lipiodol-cisplatinum suspension (LPD/CDDP) was applied by intrahepatic arterial infusion chemotherapy to treat 15 cases of inoperable hepatoma. Pre- and post-application changes in leucocytes, monocytes, platelets and lymphocytes in patients were examined. Natural killer activity was determined and analysis by two-color method was performed. After infusion chemotherapy, leucocytosis and monocytosis were quite conspicuous. NK activity was reduced after application of LPD/CDDP, but this effect may have been partly due to the influence of methylprednisolone. Cellular immunity was not influenced by LPD/CDDP infusion without low reduction of NK activity.

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Abstract:

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