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Related Experiment Videos

Warthin-Finkeldey polykaryocytes demonstrate a T-cell immunophenotype.

O W Kamel1, D P LeBrun, G J Berry

  • 1Department of Pathology, Stanford University Medical Center, California 94305.

American Journal of Clinical Pathology
|February 1, 1992
PubMed
Summary
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Warthin-Finkeldey polykaryocytes, multinucleated giant cells found in lymphoid conditions, are identified as multinucleated T lymphocytes. This finding sheds light on their role in various lymphoid disorders.

Area of Science:

  • Immunology
  • Pathology
  • Cell Biology

Background:

  • Warthin-Finkeldey polykaryocytes are multinucleated giant cells observed in diverse lymphoid conditions.
  • Their precise cellular origin and nature have remained largely undetermined.
  • These cells were initially identified in measles prodromal tonsils.

Observation:

  • The study investigated Warthin-Finkeldey-type giant cells in three lymphoid proliferations (two reactive, one neoplastic).
  • Immunohistochemical analysis utilized a panel of paraffin-reactive antibodies.
  • The presence of numerous multinucleated cells was a key feature in the selected cases.

Findings:

  • Warthin-Finkeldey polykaryocytes exhibited reactivity with Leu22 (CD43), anti-CD3, and OPD4 antibodies.
  • These reactivity patterns indicate that the cells are multinucleated T lymphocytes.

Related Experiment Videos

  • The findings provide a definitive cellular identification for these enigmatic giant cells.

    • Implications:

    • The identification of Warthin-Finkeldey polykaryocytes as T lymphocytes offers insights into their presence in various lymphoid disorders.
    • Understanding their T-cell origin may elucidate their role in the pathogenesis of these conditions.
    • This research contributes to the differential diagnosis and understanding of lymphoid proliferations.