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Dermoid cyst with crystalline inclusions in adjacent cortex: an ultrastructural study
J Haustein1, F Oppel, J Cervós-Navarro
1Institut für Neuropathologie, Freie Universität Berlin, Germany.
Clinical Neuropathology
|January 1, 1992
Summary
This study details the histology and ultrastructure of a rare central nervous system dermoid cyst, revealing keratin and inflammatory changes. Electron microscopy identified gliosis with Rosenthal fibers and crystalline inclusions in adjacent brain tissue.
Area of Science:
- Neuropathology
- Neuroscience
- Dermoid Cysts
Background:
- Central nervous system (CNS) dermoid cysts are rare tumors.
- Electron microscopic studies of CNS dermoids are scarce.
- This study investigates a unique case with situs inversus.
Observation:
- Histology revealed an epidermal matrix, keratinous debris, hair, and sebaceous glands.
- Inflammation impacted the cyst wall, and adjacent brain parenchyma showed gliosis.
- Eosinophilic rod-shaped crystals were observed in the brain tissue.
Findings:
- Electron microscopy confirmed gliosis with Rosenthal fibers near the tumor capsule.
- Prominent intracellular osmiophilic, crystalline inclusions were noted in the adjacent parenchyma.
- Glial cells and neuropil remained largely unaffected, with no gross intracellular pathology.
Implications:
- Provides novel ultrastructural insights into CNS dermoid cysts.
- Highlights the association between keratin and aseptic meningitis.
- Contributes to understanding the complex pathology of these rare tumors.