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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
Epidemiology and aetiology of acute bronchiolitis in Hong Kong infants
1Department of Paediatrics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, N.T.
Insights
This study on acute bronchiolitis in Hong Kong children found Respiratory Syncytial Virus (RSV) to be the most common cause. Unlike Western countries, a summer peak incidence was observed, with most cases having a benign clinical course.
Area of Science:
- Pediatrics
- Infectious Diseases
- Epidemiology
Background:
- Acute bronchiolitis is a common pediatric respiratory infection.
- Understanding its epidemiology and etiology is crucial for public health.
- Previous studies have primarily focused on Western populations.
Purpose of the Study:
- To describe the epidemiological, clinical, and virological features of acute bronchiolitis in Hong Kong children.
- To identify the primary etiological agents and seasonal patterns.
- To compare findings with those from Western countries.
Main Methods:
- Retrospective analysis of 1220 children admitted with acute bronchiolitis between 1985-1988.
- Utilized direct immunofluorescence, virus culture, and serology for viral identification.
- Clinical data including hospital stay, readmissions, and outcomes were recorded.
Main Results:
- Respiratory Syncytial Virus (RSV) was the predominant cause (6.6% of pediatric admissions).
- Average hospital stay was 5 days with no deaths; 10% experienced recurrent wheezing.
- A distinct summer peak incidence was observed, contrasting with Western seasonal patterns.
Conclusions:
- RSV is the leading cause of acute bronchiolitis in Hong Kong children.
- The observed summer seasonality differs from Western trends, suggesting unique epidemiological factors.
- While generally benign, recurrent wheezing and rare cases of bronchiolitis obliterans warrant attention.
Abstract:
The epidemiological, clinical and virological features of 1220 children with acute bronchiolitis admitted to the Prince of Wales Hospital, Hong Kong, from 1985 to 1988 are reported. They accounted for 6.6% of total paediatric admissions and provided a case incidence of bronchiolitis requiring admission to hospital of approximately 21 per 1000 children 0-24 months of age. The clinical course and outcome was in general benign. The average hospital stay was 5 days and there were no deaths. Ten per cent of patients were repeatedly admitted to hospital with recurrent wheezing after discharge. Two infants developed bronchiolitis obliterans. Respiratory syncytial virus (RSV) was shown by direct immunofluorescence, virus culture and serology to be the commonest cause of acute bronchiolitis in Hong Kong. Other aetiological agents included parainfluenza and influenza viruses, adenoviruses, and Mycoplasma pneumoniae. In contrast to western countries, a seasonal variation of bronchiolitis was found with a peak incidence in the summer months. The significance of these observations is discussed.
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