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Kainic acid-induced decrease in hippocampal corticosteroid receptors.

M T Lowy1

  • 1Department of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106.

Journal of Neurochemistry
|April 1, 1992
PubMed
Summary
This summary is machine-generated.

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Excitatory amino acids, like kainic acid, significantly decrease brain corticosteroid receptors, particularly in the hippocampus. This suggests a key role for these amino acids in regulating glucocorticoid and mineralocorticoid receptor levels.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Neuropharmacology

Background:

  • Corticosteroid receptors (GR and MR) are crucial for stress response and brain function.
  • The role of excitatory amino acids in regulating these receptors is not fully understood.

Purpose of the Study:

  • To investigate the effect of excitatory amino acids, specifically kainic acid, on brain corticosteroid receptor regulation.
  • To determine the impact of kainic acid on glucocorticoid receptors (GR) and mineralocorticoid receptors (MR) in various brain regions.

Main Methods:

  • Systemic administration of kainic acid to adrenalectomized and adrenal-intact rats.
  • Measurement of GR and MR binding sites (Bmax) and affinity (KD) in hippocampal, cortical, striatal, and hypothalamic tissues.
  • In vitro assays to assess direct ligand displacement.

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Main Results:

  • Kainic acid caused dose- and time-dependent decreases in hippocampal, cortical, and striatal GR, and hippocampal MR.
  • Hypothalamic GR levels were unaffected by kainic acid.
  • Decreases in receptor binding were attributed to reduced Bmax, not altered KD, indicating changes in receptor number.

Conclusions:

  • Excitatory amino acids, exemplified by kainic acid, play a significant role in regulating corticosteroid receptors, especially in the hippocampus.
  • The findings suggest the involvement of non-corticosterone factors in corticosteroid receptor plasticity.