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Exophthalmos; certain endocrinological aspects.

B SIMKIN, D W PETIT, P STARR

    California Medicine
    |February 1, 1954
    PubMed
    Summary
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    Thyroid-stimulating hormone (TSH) levels do not always increase in patients with exophthalmos and correlate inversely with thyroid activity. Treatments like thyroid extract and pituitary irradiation did not conclusively alter exophthalmos progression.

    Area of Science:

    • Endocrinology
    • Ophthalmology

    Background:

    • Exophthalmos, a condition characterized by protruding eyes, is often associated with thyroid dysfunction.
    • The role of thyroid-stimulating hormone (TSH) in the pathogenesis of exophthalmos requires further clarification.

    Purpose of the Study:

    • To investigate the correlation between blood TSH levels and thyroid activity in patients with exophthalmos.
    • To evaluate the efficacy of certain treatments in altering the course of exophthalmos.

    Main Methods:

    • Measurement of blood TSH concentrations in patients with exophthalmos.
    • Assessment of thyroid activity levels.
    • Review of treatment outcomes for thyroid extract, pituitary irradiation, and adrenocorticotropic hormone.

    Main Results:

    Keywords:
    EXOPHTHALMOS/physiologyPITUITARY GLAND, ANTERIOR/hormones

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    • TSH was not consistently elevated in patients with exophthalmos.
    • Blood TSH concentration showed an inverse relationship with thyroid activity.
    • No conclusive evidence demonstrated that thyroid extract, pituitary irradiation, or adrenocorticotropic hormone altered exophthalmos progression.

    Conclusions:

    • Elevated TSH is not a universal finding in exophthalmos.
    • The relationship between TSH, thyroid activity, and exophthalmos requires further investigation.
    • Current therapeutic interventions lack definitive efficacy in managing exophthalmos.