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Updated: Sep 18, 2026
06:02
Live Imaging to Study Microtubule Dynamic Instability in Taxane-resistant Breast Cancers
Published on: February 20, 2017
The discovery of BMS-275183: an orally efficacious novel taxane
Harold Mastalerz1, Donald Cook, Craig R Fairchild
1Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, PO Box 5100, Wallingford, CT 06492-7660, USA. harold.mastalerz@bms.com
Bioorganic & Medicinal Chemistry
|September 18, 2003
Abstract:
The evolution of 2, a C-4-methylcarbonate analogue of paclitaxel with minimal oral bioavailability and oral efficacy, into its C-3'-t-butyl-3'-N-t-butyloxycarbonyl analogue (15i), a novel taxane with oral efficacy in preclinical models that is comparable to iv administered paclitaxel, is described.
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