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Related Experiment Videos

Functional consequence of exposure to dieldrin on mammary development and function.

C Tarraf1, M El-Sabban, R Bassam

  • 1Department Biology Faculty of Arts and Sciences, American University of Beirut, PO Box 11-0236, Beirut, Lebanon.

Food Additives and Contaminants
|September 18, 2003
PubMed
Summary

Dieldrin (Dln) exposure during gestation impaired rat mammary gland development and pup growth. In cell cultures, Dln was detrimental to mammary cell growth, induced apoptosis, and altered key cellular functions.

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Area of Science:

  • Environmental Toxicology
  • Developmental Biology
  • Cell Biology

Background:

  • Dieldrin (Dln) is an organochlorine pesticide with known endocrine-disrupting properties.
  • Mammary gland development is a complex process sensitive to environmental exposures.
  • Understanding the impact of environmental toxins on reproductive health and cellular function is crucial.

Purpose of the Study:

  • To investigate the effects of dieldrin on mammary gland development in pregnant rats.
  • To evaluate the impact of dieldrin on the functional parameters of cultured mammary cells (CID-9).

Main Methods:

  • Pregnant Sprague-Dawley rats were injected with dieldrin (2.5 or 15 microM) during the last trimester.
  • Mammary gland development was assessed, and pup parameters were measured.

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  • CID-9 mammary cells were exposed to dieldrin long-term and short-term under various culture conditions.

    • Main Results:

    • Dieldrin exposure led to immature mammary alveolar structures and increased adipose tissue in dams.
    • Dieldrin-treated rats exhibited reduced pup numbers and lower pup weight.
    • Long-term dieldrin exposure harmed CID-9 cell growth, while short-term exposure induced apoptosis and altered gene expression (IL-6, TNF-alpha) and intercellular communication.

    Conclusions:

    • Dieldrin exposure during gestation negatively impacts mammary gland development and offspring growth in rats.
    • Dieldrin exhibits direct toxicity to mammary cells, affecting cell growth, viability, and function.
    • These findings highlight the potential reproductive and developmental risks associated with dieldrin exposure.