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Updated: Aug 13, 2026
Linear Amplification Mediated PCR – Localization of Genetic Elements and Characterization of Unknown Flanking DNA
Published on: June 25, 2014
PCR-assisted localization of the human SRPR gene
N Janin1, O Delattre, M Lipinski
1URA 1156 CNRS, Institut Gustave Roussy, Villejuif, France.
Abstract:
A polymerase chain reaction (PCR)-based assay has been designed that detects the presence of the human signal recognition particle receptor (SRPR) gene in inter-species somatic cell hybrids. By using hybrids containing various fragments of chromosome 11q, SRPR has been mapped to a chromosomal region flanked by the 11q23 and 11q24 breakpoints associated with the constitutional and neuroepithelioma (11;22) translocations, respectively.
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