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Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
09:44

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Published on: January 25, 2016

Role of low-molecular-weight heparins in the treatment of sudden hearing loss

Wen L Yue1, Pei Li, Pei Y Qi

  • 1Department of Otolaryngology, Pingdingshan People's Hospital, No 1, 117 you-yue Road, Pingdingshan City, Henan 467000, P.R. China.

American Journal of Otolaryngology
|September 18, 2003
PubMed

Insights

Low-molecular-weight heparins significantly improve hearing recovery rates in sudden sensorineural hearing loss (SNHL) patients. This treatment offers a safer alternative to unfractionated heparins for SNHL therapy.

Area of Science:

  • Otolaryngology
  • Pharmacology

Background:

  • Sudden sensorineural hearing loss (SNHL) lacks a universally accepted definitive treatment.
  • Investigating novel therapeutic agents is crucial for improving SNHL outcomes.

Purpose of the Study:

  • To evaluate the efficacy of low-molecular-weight heparins (LMWHs) as an adjunct therapy for SNHL.
  • To compare audiometric outcomes in SNHL patients treated with and without LMWHs.

Main Methods:

  • Retrospective analysis of 100 SNHL patients divided into two groups.
  • Group 1 received standard therapy plus LMWHs; Group 2 received standard therapy alone.
  • Audiometric data were compared pre-treatment, at day 10, and at follow-up (average 20 days).

Main Results:

  • Significant improvement in early and late audiometric outcomes was observed in the LMWH group (Group 1) compared to the control group (Group 2) (P < .05).
  • Recovery or good improvement was noted in 86% of patients in Group 1, significantly higher than in Group 2 (P < .01).
  • The average improvement rate was 84% in Group 1.

Conclusions:

  • Low-molecular-weight heparins significantly enhance the curative rate for hearing improvement in sudden sensorineural hearing loss.
  • LMWHs present a therapeutic option for SNHL without the potential risks associated with unfractionated heparins.
Abstract

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