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Published on: November 9, 2017
Multifocal peripheral neuropathy in eosinophilic fasciitis
1Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK.
Journal of Neurology
|February 1, 1992
Summary
Peripheral neuropathy can occur with eosinophilic fasciitis, a connective tissue disease. This case highlights a unique multi-focal neuropathy presentation in eosinophilic fasciitis without L-tryptophan exposure.
Area of Science:
- Neurology
- Rheumatology
- Pathology
Background:
- Eosinophilia-associated connective tissue diseases can present with neurological complications.
- Eosinophilic fasciitis is a rare connective tissue disorder characterized by inflammation of the fascia.
Observation:
- A patient with confirmed eosinophilic fasciitis developed a multi-focal peripheral neuropathy.
- Fascial biopsy showed an eosinophilic cellular infiltrate.
- Sural nerve biopsy revealed lymphocytic cuffing of epineural arterioles.
Findings:
- This specific pattern of peripheral neuropathy, characterized by lymphocytic cuffing of epineural arterioles, has not been previously reported in eosinophilic fasciitis.
- The patient had no history of L-tryptophan consumption, differentiating it from eosinophilia-myalgia syndrome.
Implications:
- This case expands the spectrum of neurological manifestations associated with eosinophilic fasciitis.
- It suggests a potential autoimmune or inflammatory mechanism linking eosinophilic fasciitis and specific peripheral neuropathies.
- Further research is warranted to understand the pathogenesis and diagnostic criteria for neuropathy in eosinophilic fasciitis.
