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Related Experiment Videos

Occupationally-induced scleroderma.

P L Pelmear1, J O Roos, W M Maehle

  • 1Occupational Health and Safety Branch Chest Clinic, Ministry of Labour, Toronto, Ontario, Canada.

Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

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Systemic sclerosis (scleroderma) may be linked to occupational exposures. This study suggests collagen disease might be work-related in susceptible individuals exposed to hand-arm vibration and silica.

Area of Science:

  • Rheumatology
  • Occupational Medicine
  • Immunology

Background:

  • Systemic sclerosis (scleroderma) is a rare multisystem disease characterized by fibrosis, vascular, and immunological abnormalities.
  • Raynaud's phenomenon is a common early symptom, and cutaneous features are prominent.
  • Previous reports suggest a potential link between scleroderma and occupational exposure to hand-arm vibration and silica.

Purpose of the Study:

  • To investigate the association between occupational exposures and collagen disease.
  • To report on additional cases of collagen disease in workers exposed to hand-arm vibration and/or silica.

Main Methods:

  • Case study reporting on four new patients with collagen disease.
  • Review of existing literature on scleroderma and occupational exposures.

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  • Analysis of exposure history, including hand-arm vibration and silica.

    • Main Results:

    • Three of the four reported patients had occupational exposure to both hand-arm vibration and silica.
    • One patient was exposed to hand-arm vibration alone.
    • These cases, combined with prior reports, support the hypothesis of work-attributable collagen disease.

    Conclusions:

    • Collagen disease, including systemic sclerosis, may be work-attributable in hypersusceptible individuals.
    • Occupational exposure to hand-arm vibration and silica are potential contributing factors.
    • Further research is warranted to confirm this association.