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Increased calmodulin levels in fibroblasts from progressive systemic sclerosis
M Seishima1, S Nagao, M Kuwahara
1Department of Dermatology, Gifu University School of Medicine, Japan.
The British Journal of Dermatology
|March 1, 1992
Abstract:
Calmodulin levels in cultured skin fibroblasts from patients with progressive systemic sclerosis (PSS) and healthy controls were measured by their ability to activate cyclic AMP-phosphodiesterase. Calmodulin levels were significantly increased in PSS fibroblasts compared with normal control fibroblasts. The changes in calmodulin content of PSS fibroblasts were also assessed by a radioimmunoassay. These findings suggest that an elevated level of calmodulin may play a role in the pathogenesis of PSS.