Cytomegalovirus-associated perianal ulcerations in AIDS

We report two patients with the acquired immune deficiency syndrome and cytomegalovirus associated perianal ulcerations. Both complained of chronic, painful, nonhealing ulcers that required surgical intervention for diagnosis and palliation. One patient developed diffuse cytomegalovirus infection and both had poor response to gancyclovir therapy. We review the pertinent clinical and pathologic findings of this serious manifestation of cytomegalovirus infection.