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Hypervitaminosis D associated with drinking milk.

C H Jacobus1, M F Holick, Q Shao

  • 1Division of Endocrinology, Beth Israel Hospital, Boston, MA.

The New England Journal of Medicine
|April 30, 1992
PubMed
Summary
This summary is machine-generated.

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Excessive vitamin D fortification in dairy milk led to vitamin D intoxication in eight patients. This highlights the critical need for careful monitoring of vitamin D levels in fortified milk products.

Area of Science:

  • Endocrinology
  • Nutritional Science
  • Public Health

Background:

  • Vitamin D fortification of milk in the U.S. began in the 1930s to prevent rickets.
  • This report details eight cases of vitamin D intoxication linked to excessive fortification of dairy milk.

Observation:

  • Eight patients presented with unexplained hypervitaminosis D.
  • All patients consumed milk from a single local dairy, with daily intake ranging from 0.5 to 3 cups.
  • Serum analysis revealed significantly elevated 25-hydroxyvitamin D levels in all patients.

Findings:

  • Seven patients exhibited hypercalcemia, and one had hypercalciuria.
  • Analysis of the milk showed extremely high concentrations of vitamin D3 (cholecalciferol), far exceeding recommended levels.

Related Experiment Videos

  • The vitamin D concentrate used for fortification, labeled as vitamin D2 (ergocalciferol), was found to contain vitamin D3.

    • Implications:

    • Incorrect and excessive vitamin D fortification of milk can cause hypervitaminosis D.
    • This underscores the necessity for stringent quality control and monitoring of vitamin D levels in fortified dairy products.
    • Ensuring accurate fortification prevents adverse health outcomes in consumers.