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Ki-1 lymphoma: a case report.

R Yowell1, E Hammond

  • 1LDS Hospital Electron Microscopy Laboratory, University of Utah, Salt Lake City 84143.

Ultrastructural Pathology
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

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This case study presents a Ki-1 lymphoma, a large cell anaplastic type, exhibiting weak leukocyte common antigen expression. Such tumors can present diagnostic challenges due to unusual immunophenotypes requiring further examination.

Area of Science:

  • Oncology
  • Pathology
  • Immunohistochemistry

Background:

  • Ki-1 lymphoma, also known as anaplastic large cell lymphoma (ALCL), is a distinct type of non-Hodgkin lymphoma.
  • Immunophenotypic analysis is crucial for diagnosing lymphomas, but some subtypes can exhibit aberrant antigen expression.

Observation:

  • A case of Ki-1 lymphoma (large cell anaplastic type) presented with weak leukocyte common antigen (CD45) expression.
  • The tumor cells were characterized by large, pleomorphic nuclei, prominent nucleoli, and a high mitotic rate.
  • Immunohistochemical analysis revealed potential for confusing immunophenotypes, including weak/negative CD45, pan T, pan B, HMB-45, S-100, and anomalous epithelial membrane antigen (EMA) positivity.

Findings:

  • Ultrastructural examination of the tumor revealed pleomorphic malignant cells with irregular nuclei and large nucleoli.

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  • The cytoplasm was abundant and complex, containing varied organelles, further characterizing the neoplastic cells.

    • Implications:

    • This case highlights the importance of considering atypical immunophenotypes in the differential diagnosis of large cell lymphomas.
    • Ultrastructural pathology can aid in clarifying diagnoses when immunohistochemistry results are equivocal or confusing.
    • Accurate diagnosis of Ki-1 lymphoma is critical for appropriate treatment strategies and patient management.