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Related Experiment Videos

Interaction between succinylcholine and cimetidine in rats.

Y Mishra1, I Ramzan

  • 1Pharmacy Department, University of Sydney, New South Wales, Australia.

Canadian Journal of Anaesthesia = Journal Canadien D'Anesthesie
|April 1, 1992
PubMed
Summary

Histamine H2 receptor blockade with cimetidine potentiates neuromuscular blockade from succinylcholine in rats. This interaction, observed in vivo, supports patient reports of adverse effects when these drugs are combined.

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Area of Science:

  • Pharmacology
  • Neuroscience
  • Anesthesiology

Background:

  • Histamine H2 receptor antagonists are widely used medications.
  • Potential interactions between H2 blockers and neuromuscular blocking agents require investigation.
  • Previous patient reports suggest an adverse interaction between cimetidine and succinylcholine.

Purpose of the Study:

  • To investigate the in vivo effects of histamine H2 receptor blockade on neuromuscular function.
  • To test the hypothesis that cimetidine adversely affects neuromuscular function during succinylcholine administration.

Main Methods:

  • Experiments were conducted in urethane-anesthetized rats under mechanical ventilation.
  • Succinylcholine was administered to achieve consistent twitch suppression.

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  • Cimetidine was administered intravenously at varying doses, and neuromuscular effects were monitored.

    • Main Results:

    • Cimetidine caused immediate potentiation of succinylcholine-induced neuromuscular blockade.
    • A transient reversal of potentiation was observed, followed by sustained potentiation.
    • Peak potentiation correlated with serum cimetidine concentration; steady-state potentiation did not.

    Conclusions:

    • Histamine H2 receptor blockade with cimetidine significantly alters neuromuscular function.
    • The observed potentiation supports clinical observations of an interaction between cimetidine and succinylcholine.
    • These findings highlight the importance of considering drug interactions in clinical practice.