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Case report 714. Postirradiation osteosarcoma after radiation of metastatic skeletal lesion
B C Toorkey1, K K Unni, D C Dahlin
1Section of Surgical Pathology, Mayo Clinic, Rochester, Minnesota 55905.
Abstract:
Two cases of postirradiation osteosarcoma are presented--one in a 76-year-old woman with breast carcinoma and subsequent osteosarcoma after radiation therapy for a metastatic lesion in the right tibia, and the other in a 16-year-old girl with hepatocellular carcinoma metastatic to the left tibia and osteosarcoma after radiation therapy to that bone. Microscopically, both cases were high-grade spindle cell lesions with osteoid production. Both patients fared poorly. This is a rare complication of radiation therapy.
