Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Long-term decrease in body fat and in brown adipose tissue in capsaicin-desensitized rats.

J Cui1, J Himms-Hagen

  • 1Department of Biochemistry, Faculty of Medicine, University of Ottawa, Ontario, Canada.

The American Journal of Physiology
|April 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Analyzing research advances in single-cell sequencing technology for immunopathological mechanisms in acute-on-chronic liver failure].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology·2026
Same author

Quantitative proteomic profiling in brain subregions of mice exposed to open-field low-intensity blast reveals position-dependent blast effects.

Shock waves·2026
Same author

Accuracy evaluation of American College of Radiology Bone Reporting and Data System (ACR Bone-RADS) for extremity bone Tumours: a study with 16 observers using World Health Organization (WHO) classification.

Clinical radiology·2025
Same author

Computed tomography (CT) and magnetic resonance imaging (MRI) findings of ovarian sclerosing stromal tumour.

Clinical radiology·2025
Same author

[Assessment of the risk of retinal arteriosclerosis by the triglyceride glucose-WHR index].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·2025
Same author

[A case of chronic hepatitis B with low-level viremia treated with tenofovir amibufenamide].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology·2025
Same journal

Blood coagulation in fish.

The American journal of physiology·2011
Same journal

Renal tubular reabsorption, metabolic utilization and isomeric fractionation of lactic acid in the dog.

The American journal of physiology·2010
Same journal

The inactivation of placental toxin by human serum.

The American journal of physiology·2010
Same journal

Adrenal function following ovariectomy in the rat.

The American journal of physiology·2010
Same journal

Capillary permeability; perfusion of frog and guinea pig hind limbs.

The American journal of physiology·2010
Same journal

Evaluation of protective measures against sunburn.

The American journal of physiology·2010
See all related articles

Capsaicin desensitization causes long-term brown adipose tissue (BAT) atrophy in rats, leading to reduced body weight and adiposity. This suggests sensory neuropeptides influence overall growth and fat regulation beyond BAT.

Area of Science:

  • Physiology
  • Metabolic studies
  • Obesity research

Background:

  • Previous studies documented rapid and persistent atrophy of brown adipose tissue (BAT) in capsaicin-desensitized rats for up to 28 days.
  • Despite BAT atrophy, these rats did not exhibit increased obesity, challenging the typical association between atrophied BAT and obesity.

Purpose of the Study:

  • To investigate the long-term effects of capsaicin desensitization on brown adipose tissue (BAT) and overall energy balance in rats.
  • To determine the duration and extent of BAT atrophy and its impact on body weight and composition.

Main Methods:

  • Rats were desensitized using capsaicin and studied at 2.5, 3.5, and 8 months post-treatment.
  • Evaluated body weight, body fat, growth, BAT weight, and biochemical markers (protein, DNA, cytochrome oxidase, uncoupling protein).

Related Experiment Videos

  • Assessed resting metabolic rates and food intake in relation to body size.

    • Main Results:

    • Significant reductions in body weight, primarily due to decreased body fat, were observed at 8 months, with lesser effects at 3.5 months.
    • Evidence of growth stunting and BAT atrophy (reduced weight and cellular components) was prominent at 8 months.
    • Resting metabolic rates and food intake were proportionally reduced in smaller-bodied rats at 8 months.

    Conclusions:

    • Long-term capsaicin desensitization leads to persistent BAT atrophy and reduced body weight, largely due to decreased adiposity and some growth stunting.
    • The findings suggest sensory neuropeptides may have a broader trophic influence on tissues like white adipose tissue, impacting overall body size and fat regulation.