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Increased frequency of coxsackie B virus IgM in women with spontaneous abortion
1Department of Medical Virology, University of Uppsala, Sweden.
Abstract:
IgM antibodies to Coxsackie B virus serotypes 1-5 (CBV 1-5) were studied by radioimmunoassay (RIA) of blood samples from women who had undergone a spontaneous abortion or given birth to a stillborn child. Results were compared with those of controls comprising healthy pregnant women who had not suffered such experiences. Among 48 women with abortions, 16 (33%) had CBV-IgM, while among the controls only three of 37 (8%) had these antibodies, a statistically significant difference (P less than 0.025). Among 21 women with a stillborn child, 11 (52%) were CBV-IgM positive, while the corresponding proportion in their controls was four of 18 (22%), a difference which is not statistically significant. It is concluded that CBV may be an important causative agent in spontaneous abortions and possibly also in stillbirths.
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