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Related Experiment Videos

Neonatal septicemia caused by pneumococci.

H Johnsson1, S Bergström, U Ewald

  • 1Department of Pediatrics, University Hospital, Uppsala, Sweden.

Acta Obstetricia Et Gynecologica Scandinavica
|January 1, 1992
PubMed
Summary

Neonatal septicemia from pneumococci (Streptococcus pneumoniae) presents with respiratory distress and leukopenia, mimicking Group B Streptococci infections. This serious condition has a 50% mortality rate in newborns.

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Area of Science:

  • Neonatal Medicine
  • Infectious Diseases
  • Pediatrics

Background:

  • Neonatal septicemia is a severe bloodstream infection in newborns.
  • While Group B Streptococci (GBS) are a common cause, other pathogens like *Streptococcus pneumoniae* (pneumococci) are increasingly recognized.
  • Understanding the specific clinical features and outcomes of pneumococcal neonatal septicemia is crucial for timely diagnosis and management.

Purpose of the Study:

  • To describe the clinical characteristics of neonatal septicemia caused by *Streptococcus pneumoniae*.
  • To discuss the pathogenesis of pneumococcal neonatal septicemia.
  • To compare the presentation and outcomes with GBS septicemia.

Main Methods:

  • Review of two in-house cases of pneumococcal neonatal septicemia.

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  • Comprehensive literature review of 40 recently published case reports.
  • Analysis of clinical presentation, laboratory findings, and outcomes.

    • Main Results:

    • Early-onset pneumococcal septicemia presents with respiratory distress and leukopenia, clinically indistinguishable from GBS septicemia.
    • Prelabor rupture of membranes preceded nearly half of the cases.
    • The mortality rate for pneumococcal neonatal septicemia is 50%, double that reported for GBS.

    Conclusions:

    • Neonatal septicemia due to *Streptococcus pneumoniae* is a significant concern with a high mortality rate.
    • Clinical presentation often mimics GBS, highlighting the need for broad-spectrum antibiotic coverage.
    • Further research into prevention and treatment strategies for pneumococcal neonatal septicemia is warranted.